研究生导师


      杰出人才


      其他教师


 

 
 
 
 
 

  研究生导师
尹艳慧 副教授
发布日期:2011-07-12 浏览次数: 字号:[ ]

 

 

 

 

尹艳慧196810月生。1987年至1993年,就读白求恩医科大学英语医学专业,获学士学位;1993年至1996年就读白求恩医科大学免疫学教研室,获硕士学位;19982001年白求恩医科大学免疫学教研室与日本德岛大学基因组研究所联合培养,获博士学位;20032005年,北京大学医学部免疫学系做博士后研究。现任北京大学医学部免疫学系副教授。

研究方向

肿瘤免疫。主要从事以肿瘤抗原为目标的肿瘤免疫研究,研究肿瘤抗原的生物学功能及其在肿瘤免疫治疗中的应用。

获奖及专利授权:

参与完成的“新的肿瘤相关抗原的发现及其应用前景研究”获国家教育部自然科学奖一等奖(2007-003),中华医学科技奖二等奖200702018U0201,北京市科学技术奖二等奖;获国家发明专利授权三项。

承担的科研课题:

1863 计划2006AA02Z486“肿瘤疫苗候选抗原HCA-587的临床前研究”3202006-2008

2、国家自然科学基金30772500 “新型肿瘤特异抗原BJ-TSA-9在肺癌表达的临床意义及其功能研究”292008-2010

3、北京市自然科学基金7071006 “肿瘤抗原的分析鉴定及可能的临床应用”502007-2009

4、国家自然科学基金81071708 “癌/睾丸抗原HCA587对肿瘤细胞周期的调控作用及其机制”312011-2013

5、国家自然科学基金:81171974  项目名称: /睾丸抗原HCA587对转录因子NF-κB的调节作用研究  602012-2015

6、方正创新药物研究基金“治疗性肝癌多肽疫苗的研制”202010,1-201112

7、北京市自然科学基金:7142087  “肿瘤/睾丸抗原HCA587在肿瘤转移中的作用及其机制研究”18万(2014,1-2016,12

8、国家自然科学基金81472645“肿瘤抗原HCA587STAT3的相互作用及其促进肿瘤转移的分子机制研究”6420151-201812

 

代表性论文:

 

  1. Xiao Song#, Wenjie Song#, Ying Wang, Jingjing Wang, Yan Li, Xiaoping Qian, Xuewen Pang, Yu Zhang, Yanhui Yin*. MicroRNA-874 functions as a tumor suppressor by targeting cancer/testis antigen HCA587/MAGE-C2. J Cancer. 2016 ;7(6):656-663.
  2. Sun X, Jin Z, Song X, Wang J, Li Y, Qian X, Zhang Y, Yin Y*. Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with                       hepatocellular carcinoma. BMC Cancer. 2015, 15:961.
  3. Hao J, Song X, Wang J, Guo C, Li Y, Li B, Zhang Y, Yin Y*. Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. Oncotarget. 2015, 6(19):42028-42039.
  4. Li X, Peng J, Pang Y, Yu S, Yu X, Chen P, Wang W, Han , Zhang J, Yin Y*, Zhang Y. Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma. Sci Rep. 2015, 5:14757.
  5. Jiaqing Hao, Rui Shen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer-testis antigen HCA587/MAGE-C2 interacts with BS69 and promotes its degradation in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2014, 449(4): 386-391.
  6. Lijie Zhang, Juanjuan Chen, Xiao Song, Weigang Wen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer/Testis antigen HCA587-derived long peptide vaccine generates potent immunologic responses and antitumor effects in mouse model. Oncology Research. 2014,21(4):193-200.
  7. Huang J, Xiao L, Gong X, Shao W, Yin Y, Liao Q, Meng Y, Zhang Y, Ma D, Qiu X.  Cytokine-like molecule CCDC134 contributes to CD8T-cell effector functions in cancer immunotherapy. Cancer Res. 2014,74(20):5734-5745.   
  8. Juanjuan Chen, Lijie Zhang, Weigang Wen, Jiaqing Hao, Pumei Zeng, Xiaoping Qian, Yu Zhang, Yanhui Yin*. Induction of HCA587-specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM. PLoS One. 2012,710):e47219.
  9. Qing-Wen Xu, Wei Zhao, Yue Wang, Maureen A. Sartor1, Dong-Mei Han, Jixin Deng,
  10. Rakesh Ponnala, Jiang-Ying Yang, Qing-Yun Zhang, Guo-Qing Liao, Yi-Mei Qu, Lu Li, Fang-Fang Liu, Hong-Mei Zhao, Yan-Hui Yin, Wei-Feng Chen, Yu Zhang, and Xiao-Song Wang. An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer. Cancer Res. 2012, 72(24):6351-6361.
  11. Wen W, Zhang L, Peng J, Chen J, Hao J, Li X, Qian X, Zeng P, Zhang Y, Yin Y*. Identification of promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the cancer-testis antigen HCA587. Cancer Sci. 2011, 102(8): 1455-1461.
  12. Wei Wang, Qian LI, Jun Zhang, Hounan Wu, Yanhui Yin, Qing Ge, and Yu Zhang. Hemokinin-1 activates the MAPK pathway and enhances B cell proliferation and antibody production.Journal of Immunology. 2010,184(7):3590-7.
  13. Yan-Li  Pang, Hua-Gang Zhang, Ji-Run Peng, Xue-Wen Pang, Shu Yu, Qiao Xing, Xin Yu, Lei Gong,Yan-hui Yin, Yu Zhang, Wei-Feng Chen. The immunosuppressive tumor microenviroment in hepatocellular carcinoma. Cancer Immunol Immunother. 2009,58877-886.
  14. Lei Liu, Guo-qing Liao, Pei He, Hong Zhu, Peng-hui Liu, Yi-mei Qu, Xiao-ming Song, Qing-wen Xu, Qian Gao, Yu Zhang, Wei-feng Chen* and Yan-hui Yin*. Detection of circulating cancer cells in lung cancer patients with a panel of marker genes. Biochem Biophys Res Commun. 2008, 372 (4): 756-760.
  15. Qiao Xing, Xue-Wen Pang, Ji-Run Peng, Yan-Hui Yin, Yan Li, Xin Yu, Shu-Pei Zhou, Yu Zhang, and Wei-Feng Chen*. Identification of new cytotoxic T-lymphocyte epitopes from cancer testis antigen HCA587. Biochem Biophys Res Commun. 2008, 372 (2):331-335.
  16. Dong XY, Peng JR, Ye YJ, Chen HS, Zhang LJ, Pang XW, Li Y, Zhang Y, Wang S, Fant ME, Yin YH*, Chen WF*. Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients. Int J Cancer. 2008, 122 (9):2038-43.
  17. Liu FF, Dong XY, Pang XW, Xing Q, Wang HC, Zhang HG, Li Y,Yin YH, Fant M, Ye YJ, Shen DH, Zhang Y, Wang S*, Chen WF*. The specific immune response to tumor antigen CP1 and its correlation with improved survival in colon cancer patients. Gastroenterology. 2008, 134 (4):998-1006.
  18. Tian C, Lv D, Qiao H, Zhang J, Yin YH, Qian XP, Wang YP, Zhang Y*, Chen WF*. TFDP3 inhibits E2F1-induced, p53-mediated apoptosis. Biochem Biophys Res Commun. 2007, 361 (1):20-5.
  19. Qiao H, Di Stefano L, Tian C, Li YY, Yin YH, Qian XP, Pang XW, Li Y, McNutt MA, Helin K, Zhang Y, Chen WF*. Human TFDP3, a Novel DP Protein, Inhibits DNA Binding and Transactivation by E2F.  J Biol Chem. 2007, 282 (1):454-66.
  20. Y-H Yin, Y-Y Li, H Qiao, H-C Wang, X-A Yang, H-G Zhang, X-W Pang, Y Zhang and W-F Chen*. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma.  British Journal of Cancer. 2005, 93:458-463.
  21. Y-Y Shi#, H-C Wang#,Y-H Yin#, W-S Sun, Y Li, C-Q Zhang, Y Wang, S Wang and W-F Chen*. Identification and analysis of tumour-associated antigens in hepatocellular carcinoma. British Journal of Cancer. 2005, 92:929-934. (the first three authors contributed equally to this work)
  22. Yunyan Li, Xueyuan Dong, Yanhui Yin, Yanrong Su, Qingwen Xu, Yuxia Zhang, Xuewen Pang, Yu Zhang and Weifeng Chen*. BJ-TSA-9, a Novel Human Tumor-Specific Gene, Has Potential as a Biomarker of Lung Cancer. Neoplasia. 2005, 7 (12):1073-1080.
  23. Dong XY, Pang XW, Yu ST, Su YR, Wang HC, Yin YH, Wang YD, Chen WF*. Identification of Genes Differentially Expressed in Human Hepatocellular Carcinoma by a Modified Suppression Subtractive Hybridization Method. Int J Cancer. 2004, 112 (2):239-48

 

 




打印本页 关闭窗口

北京市学院路38号 北京大学医学部免疫学系   邮政编码:100191
电话:010-82801155     Email:immunology@bjmu.edu.cn