研究生导师


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  研究生导师
葛 青 教授
发布日期:2011-07-12 浏览次数: 字号:[ ]

 

简历

    葛青,北京大学,医学部基础医学院免疫学系,教授

 

研究方向:

 

主要研究TNKT细胞的发育和分化,包括TNKT细胞在胸腺内的发育,胸腺迁出细胞的功能和代谢成熟,在肝脏微环境中的功能分化以及TNKT细胞在肿瘤免疫、移植免疫和粘膜免疫中的作用

 

教育经历:

北京医科大学免疫学博士学位, 1999年, 导师: 陈慰峰教授

北京医科大学医学学士学位, 1994

 

科研经历:

2009年9月,教授,博士生导师,北京大学医学部基础医学院免疫学系

2007年10月-2009年7, Director of Viral Therapeutics, SomaGenics, Inc. 美国

2006年4月-12月,Senior Scientist,Nastech Pharmaceutical Company, Inc. 美国

2005年1-20063, Senior Scientist,Galenea Corporation. 美国

2002年12月-2004年12, Research Scientist, Center for Cancer Research, Massachusetts Institute of Technology,美国

1999年7月-2002年11月, 博士后,Center for Cancer Research, Massachusetts Institute of Technology,美国

 

其它:Antiviral Research、中华微生物和免疫学杂志和中华临床免疫和变态反应杂志编委;中国免疫学会基础免疫专业委会会委员,中国免疫学会女科学家工作委员会委员。所培养的博士生多名获得国家奖学金,北京大学优秀毕业生、北京市免疫学会“青年学者奖”和基础医学院学术新锐。

 

专利:

获得4项国际专利授权和1项中国专利授权

 

科研目:

主持多项国家自然科学基金面上项目,北京市自然科学基金面上项目,高等学校博士学科点专项科研基金博导类,美国国立卫生研究院的R01SBIR phase I项目;作为骨干参与国家重点研发计划项目、国家自然科学基金创新研究群体科学基金、国家重点基础研究发展规划。获得教育部新世纪优秀人才支持计划。

 

主要发表文章(共70+:

1.      Liang Lin#, Li Cao#, Yang Liu, Ke Wang, Xinwei Zhang, Xiaodan Qin, Dandan Zhao, Jie Hao, Yingjun Chang, Xiaojun Huang, Bei Liu, Jun Zhang, Jin Lu*, Qing Ge*, B7-H3 promotes multiple myeloma cell survival and proliferation by ROS-dependent activation of Src/STAT3 and c-Cbl-mediated degradation of SOCS3. Leukemia已接收

2.      Ke Wang#, Xinwei Zhang, Yifan Wang, Gaowen Jin, Mingyang Li, Shusong Zhang, Jie Hao, Rong Jin, Xiaojun Huang, Hounan Wu, Jun Zhang*, Yingyu Chen*, and Qing Ge*, PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision. Cell. Mol. Immunol. 2018 doi:10.1038/s41423-018-0059-2

3.      Shusong Zhang#, Xinwei Zhang#, Ke Wang, Xi Xu, Mingyang Li, Jun Zhang, Yan Zhang, Jie Hao, Xiuyuan Sun, Yingyu Chen, Xiaohui Liu, Yingjun Chang, Rong Jin*, Hounan Wu*, Qing Ge*, Newly generated CD4+ T cells acquire metabolic quiescence after thymic egress. J. Immunol. 2018, 200(3):1064-1077

4.      Junxiu Shi#, Yifan Wang, Jian He, Pingping Li, Rong Jin, Ke Wang, Xi Xu, Jie Hao, Yan Zhang, Hongju Liu, Xiaoping Chen, Hounan Wu*, Qing Ge*, The intestinal microbiota contributes to colonic epithelial changes in simulated microgravity mouse model. FASEB J. 2017, 31(8):3695-3709.

5.      Xiaodan Qin#, Liang Lin#, Li Cao, Xinwei Zhang, Xiao Song, Jie Hao, Yan Zhang, Risheng Wei, Xiaojun Huang, Jin Lu*, Qing Ge*, Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis.Sci. Rep., 2017, 7:45305

6.      Liang Lin#, Fan Yan#, Dandan Zhao#, Meng Lv, Xiaodong Liang, Hui Dai, Xiaodan Qin, Yan Zhang, Jie Hao, Xiuyuan Sun, Yanhui Yin, Xiaojun Huang, Jun Zhang*, Jin Lu*, Qing Ge* Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin b1 signaling and STAT3. Oncotarget, 2016, 7(9):9844-58.

7.      Xi Xu#, Rong Jin, Mingyang Li, Ke Wang, Shusong Zhang, Jie Hao, Xiuyuan Sun, Yu Zhang, Hounan Wu*, Jun Zhang*, Qing Ge* Liver sinusoidal endothelial cells induce tolerance of autoreactive CD4+ recent thymic emigrants. Sci. Rep. 2016, 6: 19861

8.      Pingping Li#, Junxiu Shi#, Peng Zhang, Ke Wang, Jinglong Li, Hongju Liu, Yu Zhou, Xi Xu, Jie Hao, Xiuyuan Sun, Xuewen Pang, Yan Li, Hounan Wu, Xiaoping Chen*, Qing Ge* Simulated microgravity disrupts intestinal homeostasis and increases colitis susceptibility.FASEB J. 2015, 29(8): 3263-3273.

9.      Xi Xu#, Shusong Zhang#, Rong Jin, Ke Wang, Pingping Li, Liang Lin, Jie Dong, Jie Hao, Yan Zhang, Xiuyuan Sun, Xuewen Pang, Xiaoping Qian, Jun Zhang, Hounan Wu*, Yu Zhang*, Qing Ge* Retention and tolerance of autoreactive CD4+ recent thymic emigrants in the liver.J. Autoimmun.2015, 56: 87-97.

10.  Rong Jin#, Fei Teng#, Xi Xu, Yisha Yao, Shusong Zhang, Xiuyuan Sun, Yu Zhang*, Qing Ge* Redox balance of mouse medullary CD4 single positive thymocytes. Immunol. & Cell Biol. 2013, 91(10): 634-641.

11.  Fei Teng#, Yubin Zhou#, Rong Jin, Yu Chen, Xiaoyan Pei, Yuanfeng Liu, Jie Dong, Wei Wang, Xuewen Pang, Xiaoping Qian, Wei-Feng Chen, Yu Zhang*, Qing Ge*, The molecular signature underlying the thymic migration and maturation of TCR alpha beta(+) CD4(+) CD8(-) thymocytes, PLoS One, 2011, 6(10): 25567-25570. 

12.  Qing Ge #, Phillip D. Holler, Vinay S. Mahajan, Tam Nuygen, Herman N. Eisen, Jianzhu Chen*, Development of CD4(+) T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms. Proc. Natl. Acad. Sci. U.S.A., 2006, 103(6): 1822-1827.

13.  Qing Ge #, Lily Filip, Ailin Bai, Tam Nguyen, Herman N. Eisen, Jianzhu Chen*, Inhibition of influenza virus production in virus-infected mice by RNA interference, Proc. Natl. Acad. Sci. U.S.A. 2004, 101(23): 8676-8681.

14.  Qing Ge #, Ailin Bai, Brendan Jones, Herman N. Eisen, Jianzhu Chen*, Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8(+) T cells expressing the same or different T cell receptorsProc. Natl. Acad. Sci. U.S.A. 2004, 101(9): 3041-3046.

15.  Qing Ge #, Michael T. McManus, Tam Nguyen, Ching-Hung Shen, Phillip A. Sharp, Herman N. Eisen, Jianzhu Chen*, RNA interference of influenza virus production by directly targeting RNA for degradation and indirectly inhibiting all viral RNA transcription, Proc. Natl. Acad. Sci. U.S.A., 2003, 100(5): 2718-2723.

16.  Qing Ge #, Ailin Bai, Ching-Hung Shen, Herman N. Eisen, Jianzhu Chen*, CD4(+) T-cell responses to self-peptide-MHC, Trends in Immunology, 2003, 24(4): 186-189.

17.  Qing Ge #, Deborah Palliser, Herman N. Eisen, Jianzhu Chen*, Homeostatic T cell proliferation in a T cell-dendritic cell coculture systemProc. Natl. Acad. Sci. U.S.A., 2002, 99(5): 2983-2988.

18.  Qing Ge #, Hui Hu, Herman N. Eisen, Jianzhu Chen*, Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments, Proc. Natl. Acad. Sci. U.S.A., 2002, 99(5): 2989-2994.

19.  Qing Ge #, Jennifer D. Stone#, Todd M. Thompson, Jennifer R. Cochran, Mia Rushe, Herman N. Eisen, Jianzhu Chen, Stern J. Lawrence*, Soluble peptide-MHC monomers cause activation of CD8+T cells through transfer of the peptide to T cell MHC molecules, Proc. Natl. Acad. Sci. U.S.A., 2002, 99(21): 13729-13734

20.  Qing Ge #, Varada P. Rao, Brian K. Cho, Herman N. Eisen, Jianzhu Chen*, Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/MHC epitopes and strength of their interaction with T cell receptorsProc. Natl. Acad. Sci. U.S.A., 2001, 98(4): 1728-1733.

21.  Qing Ge, and Weifeng Chen*  Effect of murine thymic stromal cells on the functional maturation of CD4+CD8- medullary thymocyte subgroups.  International Immunology.  2000, 12: 1127-1133.

22.  Qing Ge, and Weifeng Chen  Phenotypical identification of the subgroups of murine TCRab+CD4+CD8- thymocytes and its implication in the late stage of thymocyte development.  Immunology. 1999, 97: 665-671.

 

 

 

 




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