研究生导师


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  研究生导师
邱晓彦 教授
发布日期:2011-07-12 浏览次数: 字号:[ ]

  

 邱晓彦教授,女,1960年出生,博士,免疫学教授,博士生导师,系主任。

受教育经历:1982.12月年获黑龙江中医学院医学学士学位;19887月年获白求恩医科大学医学病理学硕士学位;19967月获白求恩医科大学免疫学博士学位。

工作经历:198212-19858月在黑龙江中医学院附属医院病理科住院医师;19889-19928月在黑龙江中医学院附属医院病理科主治医师;199611-199811月在军事医学科学院完成博士后研究工作;199812-现在在北京大学基础医学院免疫学系做副教授、教授。

国外工作经历:19944月至19954月获世川医学奖学金在日本大阪大学微生物病研究所做访问学者;20086月至20106月在美国德克萨斯大学MD安德森做访问教授。

研究方向:肿瘤免疫学,粘膜免疫学,分子免疫

主要贡献:在国际上首次发现并报道非B细胞可以表达Ig (non B-Ig),首次报道B-Ig除了具有抗体活性,在皮肤黏膜发挥天然免疫功能外,在非B细胞谱系中发挥重要的细胞生物学功能,如促进细胞的粘附、增殖、生存及迁移。重要的是,在病理条件下,non B-Ig促进多种肿瘤的发生及转移;促进炎-癌转化。这些本土创新的研究成果已经在国际权威杂志,如Cancer Research; Leukemia; CMI;J Biol Chem; Cell Mol. Life Sci; American Journal of Pathology等杂志上发表40余篇论著,目前有关non B-Ig的研究已经形成了一个新的领域。相关研究得到了国家自然科学基金重点项目、重大国际合作项目、国家自然科学基金面上项目等15项国家级基金项目的资助。

 

近五年以通讯作者发表的SCI论文

 1.Ming Cui, Lei You, Bang Zheng, Xinmei Huang, Qiaofei Liu, Jing Huang, Boju Pan, Xiaoyan Qiu*, Quan Liao*, Yupei Zhao.High Expression of Cancer-Derived Glycosylated Immunoglobulin G Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma.Journal of Cancer,2020; 11(8): 2213-2221

2Ming Cui,Ya Hu,Bang Zheng,Shenghua Zhang,Xiang Zhang,Mengyi WangXiaoyan Qiu*,Quan Liao*,Yu-Pei Zhao.Cancer-derived immunoglobulin G: A novel marker for differential diagnosis and relapse prediction in parathyroid Carcinoma.Clinical Endocrinology. 2020;92:461-467

3Chi X, Li Y, Qiu X.V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation.
Immunology.2020;160(3):233-247.

4Qin C, Sheng Z, Huang X, Tang J, Liu Y, Xu T,Qiu X. Cancer-driven IgG promotes the development of prostate cancer though the SOX2-CIgG pathway.Prostate. 2020;80(13):1134-1144.

5Cui M, Hu Y, Zheng B, Zhang S, Zhang X, Wang M, Qiu XY, Liao Q, Zhao YP. Cancer-derived immunoglobulin G: A novel marker for differential diagnosis and relapse prediction in parathyroid carcinoma. Clin Endocrinol (Oxf).2020;92(5):461-467.

6Wu L, Xia M, Sun X, Han X, Zu Y, Jabbour EJ, You MJ, Lin P, Li S, Xu J, Han H, Bueso-Ramos CE, Medeiros LJ,Qiu X(责任作者), Yin CC. High levels of immunoglobulin expression predict shorter overall survival in patients with acute myeloid leukemia. Eur J Haematol.2020;105(4):449-459.

7Yin S, Shi Q, Shao W, Zhang C, Zhang Y, Qiu X, Huang J. Hepatocyte-Derived Igκ Exerts a Protective Effect against ConA-Induced Acute Liver Injury. Int J Mol Sci.2020, 9;21(24):9379.

8Zhenling DengXinyao WangYue LiuXinyu TianShaohui Deng,Yingchun Sun,Song WangDanxia ZhengZhuan CuiYuejuan PanLata AHuige YanXiaoyan QiuYue Wang.Single-cell RNA sequencing confirms IgG transcription and limited diversity of VHDJH rearrangements in proximal tubular epithelial cells. Sci Rep. 2020 Nov 12;10(1):19657.

9Chi ZhangLin XiaoYan HuangLi ZhangDongyang Jiang,Wenwei ShaoJie ZhengFanlei HuMing ChuJing HuangXiaoting GongYuan ZhouXiaoyan Qiu. NBIGV-DB: a dedicated database of non-B cell derived immunoglobulin variable region. Gene. 2020 Dec 22;145378.

10Yu M, Shi X, Ren M, Liu L, Qi H, Zhang C, Zou J, Qiu X, Zhu WG, Zhang YE, Wang W, Luo J. SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability.Int J Mol Sci.2020,9;21(11):4122.

11.Zihan Wang,Zihan Gen,Wenwei Shao,Enyang Liu,Jingxuan Zhang,Jingshu Tang,Pingzhang Wang,Xiuyuan Sun,Lin Xiao,Weiyan Xu,Youhui Zhang,Heng Cui, Liang Zhang, Xi Yang, Xiaohong Chang,Xiaoyan Qiu*. Cancer-derived sialylated IgG promotes tumor immune escape by binding to Siglecs on effector T cells.Cellular & Molecular Immunology. 2019 Nov 21.doi: 10.1038/s41423-019-0327-9

12.Zi-Han Geng, Chun-Xiang Ye, Yan Huang, Hong-Peng Jiang, Ying-Jiang Ye, Shan Wang, Yuan Zhou, Zhan-Long Shen, Xiao-Yan Qiu*. Human colorectal cancer cells frequently express IgG and display unique Ig repertoire. World J Gastrointest Oncol 2019 March 15; 11(3): 195-207.

13. Jingshu Tang ; Jingxuan Zhang; Yang Liu; Qinyuan Liao; Jing Huang;  Zihan Geng; Weiyan Xu; Zhengzuo Sheng; Gregory Lee; Youhui Zhang; Jinfeng Chen; Liang Zhang ; Xiaoyan Qiu*. Lung squamous cell carcinoma cells express non-canonically glycosylated IgG that activates integrin-FAK signaling. Cancer Letters. 2018.8.28, 430(28): 148-159

14. Ma J, Jiang D, Gong X, Shao W, Zhu Z, Xu W, Qiu X*. Free immunoglobulin light chain (FLC) promotes murine colitis and colitis-associated colon carcinogenesis by activating the inflammasome.Sci Rep. 2017 Jul 12;7(1):5165

15. Zhu zhua, Meng Zhangb, Wenwei Shaoa , Pingzhang Wanga , Xiaoting Gonga , Junfan Maa , Xiaoyan Qiu*, Bin Wang. Immunoglobulin M, a novel molecule of myocardial cells of mice. Int J Biochem Cell Biol. 2017,88; 172-180

16. Zhang, Shuai,Huang, Jing,Shi, Taiping,Hu, Fanlei,Zhang, Li,Zhou, Ping-Kun,Ma, Dalong,Ma, Teng ,Qiu, Xiaoyan*.DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.Oncotarget.2016,7(36):58483-58491

17. Sheng, Zhengzuo,Liu, Yang,Qin, Caipeng,Liu, Zhenhua,Yuan, Yeqing,Hu, FengZhan,Du, Yiqing,Yin, Huaqi,Xu, Tao, Qiu, Xiaoyan*. IgG is involved in the migration and invasion of clear cell renal cell carcinomaJournal of Clinical Pathology.2016.6.01,69(6):497-504

18. Shao, Wenwei ,Hu, Fanlei ,Ma, Junfan,Zhang, Chi,Liao, Qinyuan,Zhu, Zhu,Liu, Enyang,Qiu, Xiaoyan*.Epithelial cells are a sourceof natural IgM that contribute to innate immune responses.Int J Biochem Cell Biol.2016,73:19-29

19. Wang, Chong ,Xia, Miaoran ,Sun, Xiaoping,He, Zhiqiao,Hu,Fanlei,Chen, Lei,Bueso-Ramos, Carlos E,Yin, C Cameron,Qiu, Xiaoyan*.IGK with conserved IGKappaV/IGKappaJ repertoire is expressed in acute myeloid leukemia and promotes leukemic cell migration. Oncotarget.2015,6(36):39062-39072

20. Liao, Qinyuan,Liu, Wei,Liu, Yang,Wang, Fulin,Wang, Chong,Zhang, Jingxuan,Chu, Ming,Jiang, Dongyang,Xiao, Lin,Shao, Wenwei,Sheng, Zhengzuo,Tao, Xia,Huo, Lei,Yin, C Cameron,Zhang, Youhui,Lee, Gregory,Huang, Jing,Li, Zihai, Qiu, Xiaoyan*.Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis.Oncotarget.2015,6(37):40081-40094

21. Liu, Jingfang,Xia, Miaoran,Wang, Pingzhang,Wang, Chong,Geng,Immunoglobulin geneZihan,Cameron Yin, C,Zhang, Chi,Qiu, Xiaoyan*expression in umbilical cord blood-derived CD34(+) hematopoietic stem/progenitor cells. Gene.2016,575(1):108-117

22. Liu, Yang,Liu, Dan,Wang, Chong,Liao, Qinyuan,Huang, Jing,Jiang,  Dongyang,Shao, Wenwei,Yin, Cheng Cameron,Zhang, Youhui,Lee, Gregory,Qiu, Xiaoyan*.Binding of the monoclonal antibody RP215 to immunoglobulin G in metastatic lung adenocarcinomas is correlated with poor prognosis. Histopathology.2015,67(5):645-653

23. Jiang, Dongyang,Ge, Jing,Liao, Qinyuan,Ma, Junfan,Liu, Yang,Huang, Jing,Wang, Chong,Xu, Weiyan,Zheng, Jie,Shao, Wenwei,GregoryLee,Qiu, Xiaoyan*.IgG and IgA with potential microbial-binding activity are expressed by normal human skin epidermal cells.Int J Mol Sci.2015,16(2):2574-2590

 

承担国家级科研基金情况 

  1. 科技部新型冠状病毒重点研发计划, 2020YFA0707801,新型冠状病毒诱导肺上皮细胞的免疫应答及其在免疫损伤中作用及机制, 274万,在研,课题负责人
  2. 国家自然科学基金重点项目,82030044Siglecs/Sialylated-IgGSIA-IgG)作为潜在的免疫检查点在肿瘤免疫逃逸及免疫治疗中的重要作用,297万,在研,主持
  3. 国家自然科学基金面上项目,81971465,肿瘤浸润的B细胞BCR分析及其在肿瘤免疫中的意义及机制研究2020-012023-1255万,在研,主持
  4. 国家自然科学基金重大研究计划重点支持项目,91642206 上皮来源的Ig在上皮免疫稳态、炎-癌转化及上皮性肿瘤发生发展中的意义2017-012020-12200万,在研,主持
  5. 国家自然科学基金重大国际(地区)合作项目,81320108020IgG分子在急性髓细胞白血病(AML)发生发展中的意义及其作为AML治疗新靶点的应用前景,2014-012018-12280万,结题,主持
  6. 973项目,2013CB531906,针药复合麻醉机体保护机制研究,2013-012017-12100万,结题,骨干

 

科技部新型冠状病毒重点研发计划, 2020YFA0707801,新型冠状病毒诱导肺上皮细胞的免疫应答及其在免疫损伤中作用及机制;

 

国家自然科学基金面上项目,81971465,肿瘤浸润的B细胞BCR分析及其在肿瘤免疫中的意义及机制研究;

 

国家自然科学基金重大研究计划重点支持项目,91642206 上皮来源的Ig在上皮免疫稳态、炎-癌转化及上皮性肿瘤发生发展中的意义

 

 

  




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