研究生导师


      杰出人才


      其他教师


 

 
 
 
 
 

  杰出人才
葛 青 教授
发布日期:2013-12-10 浏览次数: 字号:[ ]

 

 

教育:

北京医科大学免疫学博士学位, 1999, 导师: 陈慰峰教授

北京医科大学医学学士学位, 1994

 

科研经历:

20099月至今,教授,北京大学医学部基础医学院免疫学系

2007-20097月,Director of Viral Therapeutics, SomaGenics, Inc. Santa Cruz, 美国加州

20063-12月,Senior Scientist, Nastech Pharmaceutical Company, Inc. Seattle, 美国华盛顿州

2005-20063月,Senior Scientist, Galenea Corporation. Cambridge, 美国麻州

2003-2004年,Research Scientist, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, 美国麻州

1999-2003年,博士后,Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, 美国麻州

 

其它:

2010年至今,Editorial Board of Antiviral Research

2010年至今,中华微生物和免疫学杂志审稿人

 

研究方向:

胸腺迁出细胞的胸腺后成熟及淋巴细胞的迁移、活化和记忆细胞分化

 

专利及专利申请

拥有1项专利和7项美国专利申请

 

科研目:

主持1项国家自然科学基金面上项目,1项高等学校博士学科点专项科研基金博导类,参与2项国家重点基础研究发展规划(973计划),并获得教育部新世纪优秀人才支持计划B类和北京大学医学部引进人才计划启动项目支持。曾主持1项美国NIH R01和SBIR项目。

 

发表文章目录

  1. Wang W., Li Q., Zhang J., Wu H.N., Yin Y.H., Ge Q. and Zhang Y. (2010)Hemokinin-1 activates the MAPK pathway and enhances B cell proliferation and Ab production. J. Immunol. 184(7):3590-7.
  2. Ge, Q., Ilves, H., Dallas, A., Kumar, P., Shorenstein, J., Kazakov, S.A., Johnston, B.H. Minimal-length short hairpin RNAs: The relationship of structure and RNAi activity. (2010) RNA 16(1):106-117.
  3. Ge, Q., Dallas, A., Ilves, H., Shorenstein, J., Behlke, M.A., Johnston, B.H., Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs. (2010) RNA 16(1):118-130.
  4. Ge, Q., Xu, J.J., Evans, D.M., Mixson, J.A., Yang, H.H., Lu, P.Y. Leveraging therapeutic potential of multi-targeted siRNA inhibitors.(2009)Future Med. Chem. 1(9):1671-81.
  5. Ge, Q., Evans, D., Xu, J. J., Yang, H. H. Lu, P. Y. Pulmonary delivery of small interfering RNA for novel therapeutics. Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. 2009 John Wiley & Sons Ltd. Page 269-290.
  6. Deffrasnes, C., Cavanagh, M. H., Goyette, N., Cui, K., Ge, Q., Seth, S., Templin, M. V., Quay, S. C., Johnson, P. H., Boivin, G. Inhibition of human metapneumovirus replication by small interfering RNA. (2008) Antivir Ther. 13(6):821-32
  7. Shen, C.H., Ge, Q., Talay, O., Eisen, H. N., Garcia-Sastre, A., Chen, J. Loss of IL-7R and IL-15R Expression is associated with disappearance of memory T cells in respiratory tract following influenza infection. (2008) J Immunol.180(1):171-8.
  8. Leng, Q., Ge, Q., Nguyen, T., Eisen, H. N., Chen, J. Stage-dependent reactivity of thymocytes to self-peptide-MHC complexes. (2007) Proc Natl Acad Sci U S A. 104(12):5038-43.
  9. Ge, Q., Pastey, M., Kobasa, D., Puthavathana, P., Lupfer, C., Bestwick, R. K., Iversen, P. L., Chen, J., Stein, D. A. Inhibition of multiple subtypes of influenza a virus in cell cultures with morpholino oligomers. (2006) Antimicrob Agents Chemother.50(11):3724-33.
  10. Ge, Q., Holler, P. D., Mahajan, V. S., Nuygen, T., Eisen, H. N., Chen, J.(2006) Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms. Proc Natl Acad Sci U S A.103(6):1822-7
  11. Thomas, M., Ge, Q., Lu, J. J., Klibanov, A. M., Chen, J. (2005) Polycation-mediated delivery of siRNAs for prophylaxis and treatment of influenza virus infection. Expert Opin Biol Ther. 5(4):495-505.
  12. Thomas, M., Ge, Q., Lu, J., Chen, J., Klibanov, A. M. (2005) Cross-linked small polyethylenimines: while still non-toxic, deliver DNA efficiently to mammalian cells in vitro and in vivo. Pharmaceutical Research 22(3):373-80.
  13. Thomas, M., Lu, J.J., Ge, Q., Zhang, C., Chen, J., Klibanov, A. M. (2005) Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci U S A. 102(16):5679-5684.
  14. Little, S. R., Lynn, D. M., Ge, Q., Anderson, D. G., Puram, S. V., Chen, J., Eisen, H. N., Langer, R. (2004) Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci USA 101(26):9534-9.
  15. Ge, Q., Filip, L., Bai, A., Nguyen, T., Eisen, H. N., and Chen J. (2004) Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl. Acad. Sci. USA 101(23):8676-81.
  16. Wang, C., Ge, Q., Ting, D., Nguyen, D., Shen, H., Chen, J., Eisen, H. N., Heller, J., Langer, R., Putnam, D. (2004) Molecular engineered poly(ortho ester) microspherers for enhanced delivery of DNA vaccines. Nature Materials 3(3):190-6.
  17. Ge, Q., Bai, A., Jones, B., Eisen, H. N., and Chen, J. (2004) Competition for self-peptide-MHC and cytokines between na?ve and memory CD8+ T cells expressing the same or different T cell receptors. Proc. Natl. Acad. Sci. USA 101(9):3041-6.
  18. Ge, Q., Eisen, H. N., and Chen, J. (2004) Use of siRNAs to prevent and treat influenza virus infection. Virus Research 102(1):37-42.
  19. Rudolph, M. G., Shen, L. Q., Lamontagne, S. A., Luz, J. G., Delaney, J. R., Ge, Q., Cho, B. K., Palliser, D., Mckinley, C. A., Chen, J., Wilson, I. A., and Eisen, H. N. (2004) A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects. J. Immunol. 172(5):2994-3002.
  20. Ge, Q., McManus, M. T., Nguyen, T., Shen, C, Sharp, P. A., Eisen, H. N., and Chen, J.(2003) RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc. Natl. Acad. Sci. USA, 100(5):2718-2723.
  21. Ge, Q., Bai, A., Shen, C.H., Eisen, H. N., and Chen, J.(2003) CD4+ T-cell responses to self-peptide-MHC. Trends in Immunology 24(4):186-9.
  22. Chen, J., Ge, Q., Eisen, H. N.(2003) Response to Vukmanovic and Santori: Evidence for mixed heterodimeric MHC II molecules. Trends Immunol. 24(9):473.
  23. Ge, Q., Palliser, D., Eisen, H. N., and Chen, J. (2002) Homeostatic T cell proliferation in a T-dendritic cell coculture system. Proc. Natl. Acad. Sci. USA, 99: 2983-2988.
  24. Ge, Q., Hu, H., Eisen, H. N., and Chen, J.(2002) Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of na?ve and memory T cell compartments. Proc. Natl. Acad. Sci. USA, 99: 2989-2994.
  25. Ge, Q., Hu, H., Eisen, H. N., Chen, J.(2002) Na?ve to memory T cell development during homeostasis-driven proliferation.Microbes Infect. 4(5):555-8.
  26. Schott, E., Bertho, N., Ge, Q., Maurice, M. M., and Ploegh, H.L.(2002) Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules. Proc. Natl. Acad. Sci. USA, 99(21):13735-40.
  27. Ge, Q., Stone, J. D., Thompson, M. T., Cochran, J. R., Rushe M., Eisen, H. N., Chen, J., and Stern, L. J.(2002) Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules. Proc. Natl. Acad. Sci. USA, 99(21):13729-34.
  28. Chen, J., Ge, Q., Cho, B., Eisen, H. N.(2002) T cell proliferation, differentiation, and restoration in lymphopenic individuals: for contributed volumes. Adv Exp Med Biol. 512:135-9.
  29. Ge, Q., Rao, V., Cho, B., Eisen, H. N., and Chen, J.(2001) Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/MHC epitopes and strength of their interaction with T cell receptors.Proc. Natl. Acad. Sci. USA 98(4): 1728-1733.
  30. Cho, B., Rao, V., Ge, Q., Eisen, H. N., and Chen, J.(2000) Homeostasis-stimulated proliferation drives na?ve T cells to differentiate directly into memory T cells. Journal of Experimental Medicine. 192(4): 549-556.
  31. Ge, Q., and Chen, W. F. (2000) Effect of murine thymic stromal cells on the functional maturation of CD4+CD8- medullary thymocyte subgroups.International Immunology. 12: 1127-1133.
  32. 葛青,陈慰峰(1999)小鼠胸腺质上皮细胞系MTEC1 3G11-6C10-CD4+CD8-胸腺质细胞亚群的作用。科学通报44(9): 963-967.
  33. 葛青,陈慰峰(1999) TCRab+3G11-6C10-CD4+CD8-胸腺质细胞亚群的特性分析。中国科学(C辑)29(4): 418-425.
  34. 葛青,陈慰峰(1999)小鼠TCRab+CD4+CD8-胸腺质细胞的表型分析。实验生物学报32(2): 141-149.
  35. Ge, Q., and Chen, W. F. (1999) Phenotypical identification of the subgroups of murine TCRab+CD4+CD8- thymocytes and its implication in the late stage of thymocyte development.Immunology. 97: 665-671.
  36. Yao, F. J., Ge, Q., Zhou, H. Q., Hong, M. and Ci, Y. X. (1997) Unlabeled Fluoroimmunoassay with a Europium Chelate.Microchemical Journal. 55:326-331.
  37. 肖士云,葛青,庞学文,陈慰峰(1996)胸腺基质细胞单抗Pf18-3诱导LFA-1依赖的胸腺细胞粘附聚集。中华微生物学和免疫学杂志16(5): 313-317.



打印本页 关闭窗口

北京市学院路38号 北京大学医学部免疫学系   邮政编码:100191
电话:010-82801155     Email:immunology@bjmu.edu.cn